Amino acid sequence analysis of human interleukin 1 (IL-1). Evidence for biochemically distinct forms of IL-1.
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چکیده
منابع مشابه
Amino acid sequence analysis of human interleukin 1 (IL-1). Evidence for biochemically distinct forms of IL-1
The pI-6.8 species of normal human interleukin 1 (IL-1) has been isolated by ion-exchange and reverse-phase high-performance liquid chromatography. The isolated material had a molecular weight of 18,000, and had a specific bioactivity of 1.7 X 10(7) half-maximal U/mg in the murine thymocyte proliferation assay, values similar to those obtained for murine P388D1-derived IL-1 (12), and human IL-1...
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The term interleukin 1 (IL-1) encompasses macrophage-derived polypeptide factors in man, mouse, and other animals, which stimulate murine thymocyte proliferation (1-3), and in addition activate various target cells involved in chronic inflammation (4-10). The IL-1 produced by the murine macrophage line, P388D1, has a low isoelectric point (pI) and exhibits micro-charge heterogeneity in the rang...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1985
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.162.3.790